RADIATION-INDUCED MUTATION RATES IN FEMALE MICE
نویسندگان
چکیده
منابع مشابه
Mutation frequencies in female mice and the estimation of genetic hazards of radiation in women.
The female germ cell stage of primary importance in radiation genetic hazards is the immature, arrested oocyte. In the mouse, this stage has a near zero or zero sensitivity to mutation induction by radiation. However, the application of these mouse results to women has been questioned on the ground that the mouse arrested oocytes are highly sensitive to killing by radiation, while the human cel...
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Mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germline of mismatch repair deficient Msh2 knock-out mice. Spontaneous mutation rates in homozygous Msh2(-/-) males were significantly higher than those in isogenic wild-type (Msh2(+/+)) and heterozygous (Msh2(+/-)) mice. In contrast, the irradiated Msh2(-/-) mice did not show any detectable increases in their m...
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an earlier report (IVES 1960) data were presented from tests of young I?omozygous Oregon-R males of D. melanogmter showing the comparative frequencies of sex-linked mutations observed in successive stages of spermatogenesis after treatment with acute doses of gamma rays ranging from 250r to 1Okr. Only in the 500r tests were the data sufficient to establish the mutation frequency pattern on a da...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1958
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.44.9.901